应兰州交通大学霍海峰教授和数学系景双林博士邀请，中国地质大学（武汉）黄刚教授将于2025年6月21-22日与我系相关师生进行学术研讨，并于6月22日上午举行学术报告，欢迎各位老师和研究生同学参加。

报告题目：Mathematical Modeling for Virus-Immune Dynamics with Pyroptosis

报告摘要：During the course of viral infection, the evolution of virus is inescapable and relentless. We apply three models to study and compare on evolutionary dynamics of virus in host against immune response. In absence of all specific immune responses, only one strain with the maximum basic reproductive number can survive via competitive exclusion principle; When specific immune responses are activated, multiple viral strains can coexist under immune pressure. Accompany new viral successful invasion, the diversity of viruses and the total population of infected cells would increase slowly and continuously. In particular, for human immunodeficiency virus (HIV), since its target cells (CD4+T cells) is also helper cells which support specific immune. HIV impair immune indirectly by infecting healthy CD4+T cells. We construct the third model to describe the interaction between HIV and specific immune response as measured by levels of CD4+T cells. From analysis and simulate our third model, theoretical results purpose that HIV can escape the control of specific immune response by continuous evolution to decrease the level of helper cells. Finally, the level of HIV break up and the patient enter into AIDS.

时间：6月22日09:00-10:00

地点：8-D-311

专家简介：

黄刚，中国地质大学（武汉）数学与物理学院教授、博士生导师。主要从事稳定性理论，时滞微分方程理论及其在种群动力学和传染病动力学中的应用研究。主持和参与国家自然科学基金项目四项，主持省部级教学科研项目四项，出版学术专著三部，在JMB，BMB，SIAM，JTB，JNS等知名期刊发表SCI论文40余篇，论文总被引用2000余次。

“天佑数学讲坛”由兰州交通大学数理学院发起创办，是数理学院数学系高层次常态化的学术交流平台。讲坛将不定期邀请国内外知名学者围绕数学国际前沿动态展开学术交流与探讨，通过学术报告、小型研讨会等形式为数学系师生提供向国内外知名学者学习的机会，以便能够及时准确地了解数学领域的前沿学术信息，进一步提升数学系师生的学术视野及科研水平。

数理学院

甘肃省复杂系统分析及控制基础学科研究中心

2025年6月19日